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SUMMARY:BMI SEMINAR // The SAMP8 Mouse Model:  Linking neurodegeneration i
 n aging with Epigenetics
DTSTART:20180627T121500
DTEND:20180627T131500
DTSTAMP:20260510T081840Z
UID:5134ed994621e7805953e29ff66699bba38ae422510b5c894d5f25fe
CATEGORIES:Conferences - Seminars
DESCRIPTION:Merce Pallas\, Neuropharmacology in Aging and neurodegeneratio
 n\, Dept of Farmacologia\, Neurosciences Institute\, University of Barcelo
 na\, Spain\nThe Senescence Accelerated Mice Prone 8 (SAMP8) is a mice mode
 l that has revealed cognitive and behavioral disturbances\, occurring at e
 arly age and that worsen with senescence in comparison with resistant to s
 enescence strain (SAMR1). These cognitive trends are accompanied by genera
 l hallmarks of senescence and neurodegeneration\, including Alzheimer’s 
 disease (AD) characteristics\, such as tau hypephosphorylation and aberran
 t APP processing. Therefore\, alterations in SAMP8 brain comprise a scenar
 io for the development and progression of an AD-like phenotypes including 
 the main AD traits of neuropathology and memory loss. It is knowm that\, i
 n the brain\, any small change might induce disturbances that will lead to
  emotional imbalances\, cognitive impairment\, and neurodegeneration. On t
 he other hand\, the aging process\, both in physiological and pathological
  conditions\, as occurs in AD\, can be driven by epigenetic forces. Theref
 ore\, differences among SAM strains may be explained on the basis of epige
 netics\, specifically in alterations that give rise to changes in chromati
 n status. This constitutes an additional pathway in this strain that might
  reveal new targets against harmful aging processes.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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