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SUMMARY:BMI SEMINAR // Basolateral amygdala induces trans-regional metapla
 sticity at the medial prefrontal cortex.
DTSTART:20180404T121500
DTEND:20180404T131500
DTSTAMP:20260510T105916Z
UID:d179a97c05f931760d2707a15b6931da90782ca4ba7f5cc05605aac3
CATEGORIES:Conferences - Seminars
DESCRIPTION:Gal Richter-Levin\, The Brain and Behavior Laboratory\, Univer
 sity of Haifa\, Israël\nGABAergic synapses in the basolateral amygdala (B
 LA) play an important role in fear memory generation. We have previously r
 eported that reduction in GABAergic synapses innervating specifically at t
 he axon initial segment (AIS) of principal neurons of BLA\, by neurofascin
  (NF) knockdown\, impairs fear extinction. BLA is bidirectionally connecte
 d with the medial prefrontal cortex (mPFC)\, which is a key region involve
 d in extinction of acquired fear memory. Here\, we showed that reducing AI
 S GABAergic synapses within the BLA leads to impairment of synaptic plasti
 city in the BLA-mPFC pathway\, as well as in the ventral subiculum (vSub)-
 mPFC pathway\, which is independent of BLA involvement. The results sugges
 t that the alteration within the BLA subsequently resulted in a form of tr
 ans-regional metaplasticity in the mPFC. In support of that notion\, we ob
 served that NF knockdown induced a severe deficit in behavioral flexibilit
 y as measured by reversal learning. Interestingly\, reversal learning simi
 lar to extinction learning is an mPFC-dependent behavior. In agreement wit
 h that\, measurement of the immediate early gene\, c-Fos immunoreactivity 
 after reversal learning was reduced in the mPFC and BLA\, supporting furth
 er the notion that the BLA GABAergic manipulation resulted in trans-region
 al-metaplastic alterations within the mPFC. It is interesting to ask wheth
 er such trans-regional-metaplasticity is specific to the mPFC and BLA or m
 ay be found also in other targets of the BLA\, such as the hippocampus.\n
  
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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