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SUMMARY:Inflammation initiated by perturbations of organelles integrity
DTSTART:20180206T121500
DTSTAMP:20260916T064126Z
UID:fcabcf54ee49e3383ad07cec3bd129c7b689f6139f700c9c48578f73
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Fabio Martinon\, Department of Biochemistry\, UNIL\nKey 
 cellular functions including those related to energy metabolism\, organiza
 tion of the genetic information or production of membrane-bound and secret
 ed proteins are compartmentalized within organelles. Perturbations of thes
 e cellular compartments trigger repair and adaptation programs aimed at re
 storing homeostasis. These events are often associated with inflammation. 
 Stress pathways stemming from perturbed endoplasmic reticulum (ER) for exa
 mple have been described as possible contributor to inflammatory responses
 . Here I will discuss an ER-stress related responses triggered by perturba
 tions of the nuclear envelope (NE). In particular I will focus on the mech
 anisms linking NE-stress with inflammasome activation.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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