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SUMMARY:NMR at very low temperatures: An approach to millisecond-scale str
 ucture determination and micron-scale imaging
DTSTART:20180606T171500
DTEND:20180606T191500
DTSTAMP:20260919T231251Z
UID:5feb059ab4a1bc6a6adc302692d9c6e7cb2e4513687700718a927615
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Robert Tycko\nNIH Bethesda\nUSA\nI will discuss two loosel
 y-related projects\, both involving nuclear magnetic resonance (NMR) and d
 ynamic nuclear polarization (DNP) at temperatures below 30 K.  In the fi
 rst project\, we use rapid mixing and rapid freezing to trap transient int
 ermediates in biochemical processes such as protein folding\, ligand bindi
 ng\, and oligomerization\, on time scales of several milliseconds.  The 
 resulting frozen solutions are examined by DNP-enhanced magic-angle spinni
 ng NMR.  In the second  project\, we use sensitivity gains from low te
 mperatures and DNP\, together with microcoil circuitry\, to improve the sp
 atial resolution of magnetic resonance imaging (MRI)\, with the goal of re
 aching isotropic resolution below one micron.  I will describe the techn
 ology we have developed for these projects\, along with our most recent re
 sults.
LOCATION:BCH 2201 https://plan.epfl.ch/?room==BCH%202201
STATUS:CONFIRMED
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