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SUMMARY:Chemical Dynamics in Developing Tissues
DTSTART:20180129T121500
DTSTAMP:20260407T074507Z
UID:ebc62650dd2f6823352273f8998c646a2d63754739baf9230208c7ba
CATEGORIES:Conferences - Seminars
DESCRIPTION:Yogesh Goyal\, Ph.D.\, University of Pennsylvania\, Philadelph
 ia\, PA (USA)\nBIOENGINEERING SEMINAR\n\nAbstract:\nDespite its inherent c
 omplexity\, animal development is a remarkably robust process. In some cas
 es\, however\, perturbations to developmental processes can result in abno
 rmal outcomes. I am interested in understanding the origins of such abnorm
 alities\, which are often a result of alterations in the underlying chemic
 al processes. Specifically\, I focus on abnormalities caused by mutations 
 in the Ras signaling network\, which controls a wide range of processes in
  adult and developing tissues. We have developed quantitative frameworks w
 ith spatiotemporal resolution to monitor molecular and morphological effec
 ts of perturbations in developing fly embryos. Using these tools\, we foun
 d that intrinsically active mutations can both increase and reduce the lev
 els of Ras pathway output\, a surprising\, yet highly significant result. 
 Our discovery has broad implications for the basic understanding of a larg
 e class of developmental abnormalities and urges caution when it comes to 
 considering their pharmacological treatments.  In parallel\, we have deve
 loped novel optogenetic-based tools that can be used to probe the differen
 tial contributions of dose\, duration\, and spatial range of Ras activity 
 on animal development. Together\, our multiscale approach can be used to d
 issect the underlying properties of chemical networks in developmental sys
 tems.\n\nBio:\nYogesh Goyal attended Indian Institute of Technology (IIT)
  Gandhinagar in India and received his undergraduate in Chemical Engineeri
 ng. He then joined Princeton University as a graduate student (2012-2017) 
 where he was co-advised by Stanislav Shvartsman and Trudi Schüpbach. At P
 rinceton\, Yogesh was affiliated with the department of Chemical and Biol
 ogical Engineering and the Lewis-Sigler Institute for Integrative Genomi
 cs. He just started his postdoc with Arjun Raj in Bioengineering at the Un
 iversity of Pennsylvania. Yogesh is broadly interested in developing quant
 itative experimental and computational frameworks to understand developmen
 tal and invasive systems.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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