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SUMMARY:Expanding the Genetic Code –  Chemistry in Living Systems
DTSTART:20180515T171500
DTEND:20180515T181500
DTSTAMP:20260315T161615Z
UID:de505fcd1fd3f0d373ea4e8b6aa285478b09991f0a20aea2fa1e42e4
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Kathrin Lang (TU Munich)\n The desire to study and mani
 pulate biological processes in their native environment has fuelled the de
 velopment of approaches to endow proteins with new chemical groups in vivo
 . Genetic code expansion allows the site-specific incorporation of artific
 ial\, designer amino acids into virtually any protein in living cells and 
 animals. Together with significant developments in designing and re-discov
 ering chemistries that are amenable to physiological conditions and applic
 able in living systems (in vivo chemistries)\, these methods have begun to
  have a direct impact on studying biological processes.\n\nAn emerging are
 a with enormous potential consists in the site-specific incorporation of u
 nnatural amino acids with functional groups that allow subsequent covalent
  modification of the protein with biophysical probes and small molecules v
 ia chemoselective reactions. This provides an important approach for imagi
 ng protein location in live cells and can also be used for controlling enz
 yme’s activity in vivo. Likewise\, the co-translational site-specific in
 corporation of unnatural amino acids bearing new functional groups that ar
 e inert under physiological conditions\, but become reactive to form coval
 ent linkages with biomolecules in their vicinity upon a certain trigger ha
 s become an important approach for understanding protein-protein interacti
 ons in live cells.\n\nWe envision that the approaches and technologies to 
 expand the chemical repertoire of proteins by incorporating unnatural amin
 o acids and developing new in vivo chemistries will enable the study of bi
 ological processes that are difficult or impossible to address by more cla
 ssical methods.
LOCATION:BCH 2218 https://plan.epfl.ch/?room==BCH%202218
STATUS:CONFIRMED
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