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SUMMARY:Naturally driven? — How ions get into mitochondria
DTSTART:20180205T143000
DTEND:20180205T150000
DTSTAMP:20260415T032209Z
UID:4010503cc2dd42b269a01d6cf06e60d0ab5cdafd91f18d75813d17a5
CATEGORIES:Conferences - Seminars
DESCRIPTION:Kristians Cernevics\nPhD applicant to the EDCH program\n\nABST
 RACT\nMitochondria are regarded as the “power stations” of the cell an
 d their dysfunction can\nlead to numerous aging and neurodegenerative dise
 ases such as Alzheimer’s and\nParkinson’s.However\, due to the dense\,
  lipophilic inner mitochondrial membrane it is\ndifficult to target the or
 ganelle for treatment. Lipophilic delocalized cations are often used\nto t
 arget mitochondria due to the Nernstian accumulation\, which occurs becaus
 e of the\nnegative potential over the membrane. Ion-pair model is used to 
 predict whether a\nmolecule favours the Nernstian accumulation (crossing t
 he membrane as a cation) or\nprefers to cross as an ion-pair. We tested th
 e model with density-functional theory\ncalculations on 13 molecules that 
 are well known in biological literature and in all cases\nthe prediction a
 greed with the experimental observations.However\, the model does not\npre
 dict if a molecule will accumulate inside the mitochondrial matrix. Theref
 ore\, we also\ndiscussed the main physical parameters that increase the li
 kelihood of accumulation –\nincrease in solvent-excluded surface area an
 d partition coefficient and decrease in average\nelectric potential.Our fi
 ndings can be used to make better predictions or even be useful in\ndesign
 ing new mitochondrial targeting molecules.
LOCATION:CH G1 495 https://plan.epfl.ch/?room==CH%20G1%20495
STATUS:CONFIRMED
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