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SUMMARY:Engineering Chromatin States Towards Understanding Epigenetic Regu
 lation
DTSTART:20180316T161500
DTEND:20180316T171500
DTSTAMP:20260509T054049Z
UID:a4a93ae0a8064ef0f28bae1820c8bb0f168ab48a3fd1e7f5b7c96122
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof.Yael David MSKCC\, New York\nChromatin serves as the phys
 iologically relevant form of eukaryotic genomes. Modifications to both the
  DNA and the histone-packaging proteins allow chromatin to act as a dynami
 c signaling platform to regulate genomic DNA access and ultimately establi
 sh and maintain cellular phenotypes\, so-called epigenetic regulation. Abe
 rrant chromatin signaling\, as a consequence of abnormal inputs and output
 s\, is associated with many diseases\, especially cancer. A full understan
 ding of individual chromatin signaling processes\, and their interconnecti
 vity\, is a prerequisite to the design of next-generation therapeutic agen
 ts that act to ameliorate epigenetic dysregulation. However\, it is extrem
 ely challenging to explore specific epigenetic mechanisms in the complex m
 ilieu of the cell nucleus. We developed a method that brings the precision
  and flexibility of synthetic chemistry to a native chromatin context usin
 g newly identified ultra-fast split inteins. Expanding and utilizing this 
 advance protein-engineering tool we characterize novel histone modificatio
 ns and their effect on cellular transcription.
LOCATION:BCH 2218 https://plan.epfl.ch/?room==BCH%202218
STATUS:CONFIRMED
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