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SUMMARY:From Microdishes to Microniches: 3D Micro-Environmental Control ar
 ound Single Cells. Application to Single-Cell Apico-Basal Polarization and
  Lumenogenesis Control.
DTSTART:20180221T151500
DTEND:20180221T161500
DTSTAMP:20260510T135151Z
UID:1e2d85e7ce54146471bd039ffd8152c59fddd251604e686f12c655c1
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Virgile Viasnoff\, CNRS-ESPCI ParisTech\, Paris (F) & Na
 tional University of Singapore (SG)\nBIOENGINEERING SEMINAR\n\nAbstract:\n
 The key influence of the microenvironment on cell behavior and fate is inc
 reasingly recognized. It follows that new techniques to control the 3D env
 ironment around cells are essential to understand the processes by which c
 ells probe and respond to the cues received by their microniches. Here\, w
 e present an approach that allows transforming microwells into artificial 
 microniches where the chemical coating\, the rheological properties and th
 e topographical properties can be differentially controlled on the top\, s
 ides and bottom of the wells and assembled in a combinatorial way. This te
 chnique is also compatible with high and super resolution imaging that all
 ows probing the dynamics of cell cytoskeleton and regulatory proteins with
  unprecedented resolution down to the single molecule level in 3D. We exem
 plify how these bona fide artificial microniches can be used to induce ful
 l apico-basal polarization of single epithelial cells as well as to contro
 l intercellular stresses driving the anisotropic growth of intercellular l
 umens. We will detail our recent studies on the role of mechanical forces 
 in the development of bile canaliculi in liver and explain our minimal org
 an approach.\n\nBio:\nVirgile Viasnoff is a biophysicist holding a CNRS/NU
 S professor appointment.  He is the Head of a joint CNRS/National Univers
 ity of Singapore lab. His group at the Mechanobiology Institute of Singapo
 re studies how environmental sensing influences cell-cell interactions. In
  particular\, combining microfabrication technics\, original optical detec
 tion and biophysical approaches\, they study the role of mechanical forces
  in the establishment/homeostasis/loss of epithelial polarization in the c
 ontext of liver development and cancer progression.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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