BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Tracking Nanoparticles inside Cells at High Resolution: Significan
 ce for Medicine and Toxicology
DTSTART:20180219T131500
DTEND:20180219T141500
DTSTAMP:20260408T080227Z
UID:9cb6a44526260f0965331b13d29733115625ca8847c8bdeccb947095
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Alexandra E. Porter\, Imperial College London\nMultimoda
 l materials combine materials with complementary imaging and therapeutic c
 apabilities into one platform and are receiving increasing interest in the
  field of scancer theranostics. These surface modified nanomaterials carri
 ers offer several advantages\, such as high drug loading capacity\, abilit
 y to evade efflux pump action at the brain microvessels\, and size-tunabil
 ity.  By integrating different component modules into these platforms\, i
 t should possible to combine the qualities of each module to modulate thei
 r properties for flexible treatment of a range of diseases.  We are devel
 oping multifunctional luminescent nanomaterials for delivery of chemothera
 peutic drugs to treat breast cancers and for delivery of therarpeutics acr
 oss biological barriers\, such as the lung epithelium and blood brain barr
 ier.  Before these materials can be used commercially\, it is vital to as
 sess their safety to human health and the environment.  Thus\, we are als
 o adapting these materials to assess the potential health and ecological c
 onsequences of the increasing prevalence of new classes of nanoparticulate
  material in the environment. \n \nThe talk will describe our working un
 derstanding of the fundamental properties of current and new generation mu
 ltimodal bionanomaterials and how their physicochemical properties might r
 elate to their bioreactivity\, translocation and ultimate fate\, weighed a
 gainst the advantages such materials offer in nanomedicines. In this paper
 \, I will discuss our work on application correlative\, multiscale spectro
  microscopy techniques to characterise the nanomaterials-biology interface
 . Key challenges include the need for high spatial and energy resolution a
 llowing discrimination of subtle chemical signatures. Information about dy
 namic processes is also required to track how these nanomaterials degrade 
 and transform in different environments in situ\, since alterations to the
 ir physicochemistry will alter their ultimate bioreactivity.  The talk wi
 ll highlight new insights that are gained by using advanced characterisati
 on techniques\, and discuss the benefits of correlative approaches between
  in situ X-ray and electron spectroscopies.\n\nBio: Alexandra Porter is a 
 Professor of Bio-Imaging and Analysis at the Department of Materials at Im
 perial College. She holds a Master of Engineering from Oxford University\,
  and a PhD from Cambridge University in Biomedical Materials.  She worked
  as a postdoctoral research fellow at the Lawrence Berkeley National Labor
 atory\, MIT and The Nanoscience Centre Cambridge under Sir Mark Welland an
 d Prof. Paul Midgley.  She held the Oppenheimer Research fellowship for p
 hysical sciences at Cambridge University and a Junior Research Fellowship 
 at Newhall College\, Cambridge.\n 
LOCATION:MXF 1 https://plan.epfl.ch/?room==MXF%201
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR