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SUMMARY:BMI SEMINAR // Cerebral cortex interneuron myelination: Fundamenta
 l mechanisms and clinical implications
DTSTART:20181219T121500
DTEND:20181219T131500
DTSTAMP:20260414T175437Z
UID:0227747cb6c7e3b361c020e5c15aa084f7b3f887f62e32ae916e3780
CATEGORIES:Conferences - Seminars
DESCRIPTION:Steven Kushner\, Department of Psychiatry\, Erasmus MC: Univer
 sity Medical Center Rotterdam\, The Netherlands\nPrevious studies have ide
 ntified well-replicated structural abnormalities of white matter in schizo
 phrenia\, including in first-episode and treatment-naive patients. However
 \, the causality of these changes has been difficult to ascertain.  Seemi
 ngly unrelated abnormalities of parvalbumin (PV) interneurons in schizoph
 renia post-mortem neocortex have also been consistently observed\, the le
 ading candidate mechanism for disease-related deficits in gamma oscillatio
 ns.  In my talk\, I will describe our findings combining family-based rar
 e variant genetic discovery with induced pluripotent stem cell (iPSC) mode
 ling which now suggest that oligodendrocyte progenitor cell dysfunction sh
 ould be considered as a candidate etiological cell type in schizophrenia. 
 Moreover\, I will also discuss our discovery that fast-spiking PV interneu
 rons in the neocortex and hippocampus are universally myelinated and exhib
 it a novel form of activity-dependent myelin plasticity\, which could ther
 efore represent an important locus of pathophysiological convergence.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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