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SUMMARY:Single-cell biology of Salmonella in infected host tissues
DTSTART:20180220T121500
DTSTAMP:20260916T014032Z
UID:2290a47c417fe795728009454b92adcd8a5d56cf10a45b403fa7c47b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dirk Bumann\, Biozentrum\, University of Basel\nPathogen prope
 rties in infected host tissues are crucial for disease and control. Novel 
 single-cell technologies reveal an astonishing diversity of pathogen cells
  with disparate molecular compositions\, fates\, and impact on overall dis
 ease progression. A current key challenge is to understand the relation be
 tween these various pathogen subsets and their respective host microenviro
 nments. As a first step towards this goal\, we have implemented 3D imaging
  methods for infected tissues at nm to cm scales. We use these methods to 
 determine how host structures modulate Salmonella sensitivity to antimicro
 bial chemotherapy. Our results show strong host impact across a wide range
  of scales and identify a particular compartment in spleen that provides a
  niche for long-term Salmonella survival during treatment with potent fluo
 roquinolone or beta-lactam antibiotics. The increasingly detailed understa
 nding of important physico-chemical parameters in the host paves the way f
 or establishing suitable in vitro models for in-depth molecular analysis u
 nder relevant in vivo-like conditions.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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