BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Complementary molecular cues ensure a robust microtubule-dependent
  nuclear positioning in the Drosophila oocyte
DTSTART:20180418T140000
DTEND:20180418T153000
DTSTAMP:20260407T074510Z
UID:5fcb1cebb779533b507448ac841c5d6c6714193cc48b90ce5e851984
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Antoine Guichet - INSTITUT JACQUES MONOD\nControlling the 
 localization of the nucleus is crucial for a variety of cellular functions
 . In the Drosophila oocyte\, nuclear asymmetric positioning is essential 
 for the reorganization of the microtubule (MT) arrays that control the pol
 arized transport of axis determinants. Combining quantitative 3D live imag
 ing and laser ablation-mediated force analysis reveals that nuclear positi
 oning is ensured with an unexpected level of robustness. We show that the 
 nucleus is pushed to the oocyte antero-dorsal cortex by MTs\, and that its
  migration can proceed through distinct tracks. One migratory route is fav
 oured by centrosome-associated MTs. Alternatively\, a separate route is pr
 omoted by the MT-associated protein Mud/NuMA asymmetrically localized in a
  Asp-dependent manner at the nuclear envelope hemisphere where MT nucleati
 on is higher. Our results demonstrate that centrosomes do not provide an o
 bligatory driving force for nuclear movement\, but together with Mud\, con
 tribute a set of complementary mechanisms that ensure the robustness of as
 ymmetric nuclear positioning.\n\n 
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR