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SUMMARY:Role of the RNA-binding protein NONO in circadian gene expression 
 and metabolism
DTSTART:20180307T100000
DTEND:20180307T110000
DTSTAMP:20260916T014013Z
UID:7161673db250dd193dcbbbea9f80af651bcb60b994581cafc15d35b1
CATEGORIES:Conferences - Seminars
DESCRIPTION:Giorgia BENEGIAMO\, Ph.D.\, Chronobiology and Sleep Research G
 roup\, Institut für Pharmakologie und Toxikologie\, Universität Zürich 
 (CH)\nSEMINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANC
 E (LIMNA)\n\nAbstract:\nThe mechanisms by which feeding and fasting drive 
 rhythmic gene expression for physiological adaptation to daily rhythm in n
 utrient availability are not well understood. In my PhD work I found that\
 , upon feeding\, the RNA binding protein NONO accumulates within speckle-l
 ike structures in liver cell nuclei. Combining RNA-immunoprecipitation and
  sequencing (RIP-seq)\, I found that an increased number of RNAs are bound
  by NONO after feeding. I further discovered that NONO binds and regulates
  the rhythmicity of genes involved in nutrient metabolism post-transcripti
 onally.\n\nFinally\, I found that disrupted rhythmicity of NONO target gen
 es has profound metabolic impact. Indeed\, NONO-deficient mice exhibit imp
 aired glucose tolerance and lower hepatic glycogen and lipids. Accordingly
 \, these mice shift from glucose storage to fat oxidation\, and therefore 
 remain lean throughout adulthood. In conclusion\, my study demonstrated th
 at NONO post-transcriptionally coordinates circadian mRNA expression of me
 tabolic genes with the feeding/fasting cycle\, thereby playing a critical 
 role in energy homeostasis.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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