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SUMMARY:Progeria and Proteomics - an Overview
DTSTART:20180430T100000
DTEND:20180430T110000
DTSTAMP:20260508T120350Z
UID:a8607311392338350273ee94d0015d7e29ec5a16719af2a7575b2b86
CATEGORIES:Conferences - Seminars
DESCRIPTION:Ludger GOEMINNE\, Ph.D.\, VIB-UGent Center for Medical Biotech
 nology\, Ghent University (B)\nSEMINAR of the LAUSANNE INTEGRATIVE METABOL
 ISM and NUTRITION ALLIANCE (LIMNA)\n\nAbstract:\nFor many non-communicable
  diseases\, mechanisms acting exclusively at the protein level (e.g. synth
 esis\, degradation\, aggregation\, post-translational modification) are ma
 jor contributors to loss of cell function. This is also true for Hutchins
 on-Gilford progeria\, a rapid aging disease for which good model systems w
 ere lacking at the time.\n\nDuring my master's thesis\, I was able to par
 tially mimic the disease in healthy cells using both genetic and chemical 
 treatments. However\, to fully uncover the complex molecular network for
  diseases such as progeria\, omics approaches are necessary. Therefore\, d
 uring my PhD\, I focused on developing MSqRob: a versatile R package with
  a graphical user interface that allows easy quantification of both simple
  and complex proteomics data. During my talk\, I will show the rationale
  behind MSqRob and demonstrate its performance.\n\nFurthermore\, I will i
 ntroduce our newest addition to quantify proteomics data for which peptide
 s are completely missing in one condition. Although very different in nat
 ure\, both my master's and my PhD work have indirectly made a contributio
 n to elucidate pathological protein network perturbations.\n \n\n(*) IMP
 ORTANT NOTICE: All external participants have to pass through SV Reception
 /Welcome Desk to be able to access to AI 1153. Contact person to call at a
 rrival at SV Reception Desk: Administrative Assistant (ext. 3 95 22).
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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