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SUMMARY:Revealing chromatin dynamics on the single-molecule scale
DTSTART:20180308T171500
DTEND:20180308T181500
DTSTAMP:20260510T164725Z
UID:fcc528809fb2e23fd80277e8870229217f19468d44592db3478c0b4b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Beat Fierz\n\nEPFL\nThe elucidation of the structure and
  dynamics of chromatin\, the nucleoprotein complex organizing the eukaryot
 ic genome\, is a problem spanning orders of magnitude in spatial (Å to mi
 crometers) and temporal (microseconds to hours) scales. Chromatin structur
 e and dynamics control access to the genomic DNA\, thereby forming a criti
 cal gate for gene regulation. These processes are tightly controlled by ef
 fector proteins that bind to combinations of chemical modifications on the
  chromatin surface. The dynamic architecture of chromatin is currently sti
 ll poorly understood\, due to a lack of methods suitable to study large he
 terogeneous complexes.\n\nWe combine chemical chromatin synthesis and sing
 le-molecule imaging to study how multivalent effector proteins dynamically
  interact with modified chromatin and control chromatin structure and dyna
 mics. Our approaches allowed us dissect the dynamics of key protein factor
 s in gene silencing. Conversely\, using a multimodal single-molecule Förs
 ter resonance energy transfer (smFRET) approach we revealed the structural
  states and their interconversion kinetics in chromatin fibers. Chromatin 
 thus samples a complex energy landscape modulated by chemical modification
 s and interacting proteins\, controlling gene function.
LOCATION:BCH 2201 https://plan.epfl.ch/?room==BCH%202201
STATUS:CONFIRMED
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