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SUMMARY:Regulation of Liver Sex-Dimorphic Gene Expression and Metabolism b
 y Gut Microbiota
DTSTART:20180322T101500
DTSTAMP:20260920T122729Z
UID:712d8cb7efd62ffc7aaed5a35ccbcf60765fba0315a7f949ae2cbf8c
CATEGORIES:Conferences - Seminars
DESCRIPTION:Frédéric Gachon\, Ph.D.\, EPFL\nBIOENGINEERING SEMINAR\n\nAb
 stract:\nGut microbiota and the circadian clock are both key regulators of
  metabolic processes. Although recent evidence points to the impact of the
  circadian clock on microbiota\, gut microbiota effect on diurnal host gen
 e expression remains elusive. A transcriptome analysis of germ-free mice r
 eveals subtle changes in circadian clock gene expression in liver\, intest
 inal\, and white adipose tissue. However\, a lack of microbiome leads to t
 he loss of liver sex-dimorphism and alters the sex-specific rhythmic expre
 ssion of genes involved in lipid\, amino acid\, and pyridine metabolism\, 
 as well as xenobiotic detoxification. Consequently\, rhythmic sex-dimorphi
 c metabolism is also strongly altered in germ-free mice. Additional eviden
 ces suggest that exposure to microbiota-derived metabolites is required fo
 r the maturation of the pituitary\, in addition to the activation of a sub
 set of signaling pathway in adults. As a consequence\, sex-dimorphic growt
 h hormone and sex hormones secretion is altered in germ free mice\, leadin
 g to the observed loss of liver sex-dimorphism. These results emphasize th
 e mutual interaction of gut microbiota and its host even on unexpected fun
 ctions.\n\nBio:\n\nPositions:\n\nNov 2017 – Present\nSenior Scientist\nE
 PFL\n\nNov 2014 – Present\nMaître d'Enseignement et de Recherche\nEPFL\
 n\nSept 2012 – Present\nSenior Expert\nCompany Name Nestlé Institute of
  Health Sciences\n\nSept 2009 – Aug 2012\nAssistant professor\nUniversit
 é de Lausanne\n\nJul 2006 – Aug 2009\nResearch Group Leader\nINSERM\n\n
 Oct 2001 – Jul 2006\nPost-doctoral assistant\nUniversité de Genève\n\n
 Education:\n\n2008 – 2009\nUniversity of Montpellier\nHDR Degree\, Bioch
 emistry-Molecular Biology\n\n1997 – 2001\nUniversity of Montpellier\nPhD
 \, Biochemistry-Molecular Biology\n\n1997\nUniversity of Montpellier\nDEA\
 , Biologie-Santé\n\n1994 – 1997\nEcole Nationale Supérieure de Chimie 
 de Montpellier\nMaster degree\, Chemistry\n\n1992 – 1994\nAix-Marseille 
 University\nDUT Degree\, Chemistry
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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