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SUMMARY:BMI SEMINAR // Friends become enemies: Genomic instability and aut
 ophagy converge to promote neurodegeneration
DTSTART:20180704T121500
DTEND:20180704T131500
DTSTAMP:20260609T230407Z
UID:5dc85e34c2ab892d886ec0fd227241008be180820c349cbfe28069e1
CATEGORIES:Conferences - Seminars
DESCRIPTION:Sherif El-Khamisy\, Department of Molecular Biology and Biotec
 hnology\, The University of Sheffield\, UK\nThe human genome is under cont
 inuous threat from environmental toxins and endogenous sources generated d
 uring normal metabolic activities. We have previously shown that failure t
 o repair genomic breaks resulting from oxidative DNA breaks and those feat
 uring protein-DNA cross-links lead to neurological disease in man\, such a
 s ataxia telangiectasia and spinocerebellar ataxia with axonal neuropathy.
  I will present and discuss data showing that genomic instability also und
 erpin neurological demise associated with dementia and ALS. Accumulation o
 f genomic breaks perturbs nuclear and mitochondrial gene transcription and
  reveals a new paradigm connecting DNA repair and autophagy with exciting 
 opportunities for therapeutic intervention.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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