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SUMMARY:Special LMNN Seminar - Mechanisms of prion-like propagation of pro
 tein aggregates
DTSTART:20180419T090000
DTEND:20180419T100000
DTSTAMP:20260919T052644Z
UID:a547d3182869c69b4abbb8ec82aae582342d7ed413950527c9af62c2
CATEGORIES:Conferences - Seminars
DESCRIPTION:Carmen Nussbaum\, Zentrum für Molekulare Biologie der Univers
 ität Heidelberg (ZMBH) Deutsches Krebsforschungszentrum (DKFZ) Universit
 ät Heidelberg\, GERMANY\nMany neurodegenerative diseases such as Alzheime
 r’s disease or Parkinson’s disease are associated with the gradual acc
 umulation and characteristic spreading of pathological proteins. Factors i
 nvolved in the prion-like propagation of protein aggregates remain\, howev
 er\, largely elusive. I will present our ongoing work using the nematode C
 aenorhabditis elegans as a model system to discover and investigate cellul
 ar pathways and molecular components that influence the intercellular spre
 ading of disease-associated proteins (e.g.\, α-Synuclein). I will further
  discuss our progress in examining how the disaggregation activity of the 
 human Hsp70 chaperone system is modulating diverse aggregation-prone subst
 rates in vitro and in vivo. A better understanding of the role of the cell
 ular protein quality control system in prion-like propagation of misfolded
  proteins might identify new druggable targets for the treatment of neurod
 egenerative diseases.\n 
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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