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SUMMARY:Remodelling a motor on the go: Dynamic exchange in the bacterial f
 lagellar motor and Type 3 secretion system and possible roles in motor fun
 ction
DTSTART:20180529T121500
DTSTAMP:20260405T222509Z
UID:5ce4aa0822c1a0929a00d04c56044e48b7c6b180ec8e3f58c37d85b8
CATEGORIES:Conferences - Seminars
DESCRIPTION:Judith Armitage\, University of Oxford\, UK\nThe bacterial fla
 gellar motor is the most complex rotary motor identified in biology. A cen
 tral transmembrane rotor spins at up to 1300Hz against a ring of ion trans
 locating stators attached to the cell wall\, rotating an external helical 
 flagellum to push the bacterium forward. The evolutionally related T3SS us
 ed the equivalent of the rotor to inject toxins into host cells via an ext
 racellular needle. Using a combination of molecular genetics\, behavioural
  analysis\, in vivo fluorescence microscopy and biophysics we have shown
  that neither the flagellar motor nor the T3SS are stable structures\, but
  components are being exchanged with pools of proteins while the motor are
  functioning. We have also shown that this exchange is linked to the funct
 ion of the two systems\, indicating that bacteria can rapidly remodel mult
 i- protein complexes in response to external conditions.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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