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SUMMARY:High-Resolution\, Integrative Modelling of Biomolecular Complexes 
 from Fuzzy Data
DTSTART:20180501T100000
DTSTAMP:20260919T215346Z
UID:2729242ffb338a87753c035b7ed7241d398e6892607199f7d25bfea9
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Alexandre Bonvin\, Utrecht University (NL)\nBIOENGINEERI
 NG SEMINAR\n\nAbstract:\nThe prediction of the quaternary structure of bio
 molecular macromolecules is of paramount importance for fundamental unders
 tanding of cellular processes and drug design. In the era of integrative s
 tructural biology\, one way of increasing the accuracy of modelling method
 s used to predict the structure of biomolecular complexes is to include as
  much experimental or predictive information as possible in the process.\n
 \nWe have developed for this purpose a versatile information-driven dockin
 g approach HADDOCK (http://www.bonvinlab.org/software). HADDOCK can integr
 ate information derived from biochemical\, biophysical or bioinformatics m
 ethods to enhance sampling\, scoring\, or both. The information that can b
 e integrated is quite diverse: interface restraints from NMR\, mutagenesis
  experiments\, or bioinformatics predictions\; shape data from small-angle
  X-ray scattering and\, recently\, cryo-electron microscopy experiments. I
 n my talk\, I will illustrate HADDOCK’s capabilities with various exampl
 es.\n\nBio:\nAlexandre Bonvin (1964) studied Chemistry at Lausanne Univers
 ity\, Switzerland and obtained his PhD at Utrecht University in the Nether
 lands (1993). After two post-doc periods at Yale University (USA) and the 
 ETHZ (CH) he joined Utrecht University in 1998 where he was appointed full
  professor of computational structural biology in 2009. In 2006\, he recei
 ved a prestigious VICI grant from the Dutch Research Council. He was direc
 tor of chemical education from February 2009 until February 2012 and vice 
 head of the Chemistry Department from 2010 until April 2012. He is partici
 pating to several EU projects including the BioExcel Center of Excellence 
 in Biomolecular Simulations. His work has resulted in over 200 peer-review
 ed publications.\nISI Web of Science\, author ID: A-5420-2009 Google Schol
 ar Citations ORCID: http://orcid.org/0000-0001-7369-1322\n 
LOCATION:AI 1 153 https://map.epfl.ch/theme/generalite_thm_plan_public?dim
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STATUS:CONFIRMED
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