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SUMMARY:Connectomics to Biotextilogy - Thinking Inversely and Recursively 
 to Engineer Advanced Materials and Medical Devices
DTSTART:20180514T121500
DTEND:20180514T131500
DTSTAMP:20260510T054628Z
UID:860cee3de1046251af26f440e3dbe86e4496e3fcf5a32ef90003eef9
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof.  Melissa L. Knothe Tate\, University of New South Wales
 \, Sydney (AUS)\nBIOENGINEERING SEMINAR\n(sandwiches will be served)\n\nAb
 stract:\nThrough combination of novel microscopy protocols for imaging liv
 e cells and tissues as well as experimental mechanics methods\, we have be
 gun to elucidate mechanisms underpinning emergent properties of hierarchic
 al materials such as tissues [1\,2]. We refer to the process as Microscopy
  Aided Design And Manufacture (MADAMe). We apply this paired imaging and c
 omputational technology approach to engineer advanced materials that emula
 te the smart mechanical properties of tissues. These materials have applic
 ations in diverse arenas\, from medical implants to the transport and spor
 ts industries. Our "bottom up" approach to emulating mechanically responsi
 ve natural materials integrates the fields of multiscale biomechanics and 
 mechanobiology in novel ways and underscores the role of mechanics in lif
 e. It also elucidates how "brainless" cells adapt to dynamic mechanical e
 nvironments by constantly weaving and thereby adapting their own niche [3
 ]. In addition\, our connectomics approach to understanding cell networks 
 in situ\, in tissues as diverse as brain and bone\, provides a basis for a
  new approach to diagnostics\, predicting emergent disease states using an
  epidemiological approach in cell populations within individual patients [
 3\,5\,6]. Challenges to the connectomics approach include acquisition\, ha
 ndling and archiving of massive data sets\, discrepancies in technical cap
 acities (e.g. resolution) of imaging methods\, and hard and software appro
 aches\, as well as bridging and upskilling of research teams to apply a tr
 ansdisciplinary approach using innovative conceptual\, experimental\, and 
 translational approaches. This talk integrates our understanding of cells\
 , expert tissue prototypers\, and their networks\, to emulating cellular a
 pproaches to engineer and manufacture materials and medical devices of the
  future.\n\n[1] Knothe Tate ML (2017) Science/AAAS\, A New Age in Scanning
  Electron Microscopy: Applications in the Life Sciences\, pp. 19-23.\n[2] 
 Ng J et al. Sci Reports (2017) 7\, 40396.\n[3] Knothe Tate ML et al. A
 dv Healthcare Mat (2016) 5\, 1581.\n[4] Knothe Tate ML et al. BioArchite
 cture (2016) 6\, 85.\n[5] Eberle A-L et al. J Microscopy (2015) 259\, 114
 .\n[6] Pereira A et al. PLoS Comp Biol (2016) 12\, e1005217.\n\nBio:\n\nEx
 perience\nsince 2013:\nUniversity of New South Wales\, Sidney (AUS)\nProfe
 ssor\, Paul Trainor Chair of Biomedical Engineering\n\n2009-2013:\nCase We
 stern Reserve University\, Cleveland\, OH (USA)\nProfessor\, Mechanical & 
 Aerospace and Biomedical Engineering\n\n2004-2009:\nCase Western Reserve U
 niversity\, Cleveland\, OH (USA)\nAssociate Professor\, Mechanical & Aeros
 pace and Biomedical Engineering\n\n2001-2004:\nCase Western Reserve Univer
 sity\, Cleveland\, OH (USA)\nAdjunct Assistant Professor\, Mechanical & Ae
 rospace and Biomedical Engineering\n\n2001-2002:\nUniversity and ETH Zuric
 h (CH)\nAdjunct Lecturer\, Institute of Biomedical Engineering and Medical
  Informatics\n\n2000:\nMount Sinai School of Medicine\,  New York (USA)\n
 Visiting Professor\, Department of Orthopaedics\n\n1998-2000:\nUniversity 
 and ETH Zurich (CH)\nLecturer\, Head of Mechanobiology Research Group\, In
 stitute of Biomedical Engineering and Medical Informatics\n\n1997-2000:\nA
 O/ASIF Research Institute\, Davos (CH)\nHead of Bone Mechanobiology Resear
 ch Group\n\n1997-1998:\nETH Zurich (CH)\nPostdoctoral fellow\, Institute o
 f Biomedical Engineering and Medical Informatics\n\nEducation\nETH Zurich 
 (CH)\nPh.D.\, Mechanical Engineering and Biomedical Engineering (1998)\nM.
 S.\, Mechanical Engineering (1994)\n    \nStanford University (USA)\nB.
 S.\, Mechanical Engineering and B.S.\, Biological Sciences (dual degrees\,
  1988)
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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