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SUMMARY:Structure vs. Function: Chromosome architecture and the regulation
  of gene expression
DTSTART:20180522T140000
DTSTAMP:20260407T113848Z
UID:5fb06da69735906f1904dd19aadfc06e5015c3f1973e002d6ba6a6f0
CATEGORIES:Conferences - Seminars
DESCRIPTION:Luca Giorgetti\, Friedrich Miescher Institute for Biomedical R
 esearch\nAccurate regulation of gene expression is fundamental for the cor
 rect development of tissues in all living organisms. In mammals\, control 
 of gene expression relies critically on DNA sequences named enhancers\, wh
 ich are often located at very large genomic distances from the gene that t
 hey control. How such distant regulatory sequences act specifically on one
  or a limited number of genes\, despite the large intervening stretches of
  non-coding genomic DNA is unknown. Emerging evidence suggests that the th
 ree-dimensional structure and dynamics of chromosomes inside cell nuclei p
 lays a key role in the communications between enhancers and their target g
 enes. However\, the precise mechanism that link chromosome conformation to
  gene regulation remain largely unknown. What is the exact structure of th
 e chromatin fiber within chromosomes? Which proteins control it and how? H
 ow does chromosome structure vary from cell to cell and in time? What are 
 the biophysical principles by which chromosome folding determine the activ
 ity of enhancers? Addressing these questions requires to quantitatively me
 asure gene expression and chromosome conformation\, including their cell-t
 o-cell and temporal variability\, and to interpret the data using physical
  models. Research in our lab uses genomic engineering\, molecular biology 
 experiments designed to provide quantitative data\, single-cell assays and
  physical models to understand the mechanisms by which three-dimensional c
 hromosome structure and dynamics control transcriptional regulation by enh
 ancers.   \n 
LOCATION:BSP 727 https://plan.epfl.ch/?room==BSP%20727
STATUS:CONFIRMED
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