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SUMMARY:mTOR and Lysosomes in Growth Control
DTSTART:20190429T121500
DTSTAMP:20260406T081515Z
UID:5fbee3c2369c5c451e203c94e4dbf85cca3fb63ded9083f8a9364d43
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. David Sabatini\, Whitehead Institute for Biomedical Rese
 arch\, Massachusetts Institute of Technology\, Cambridge\, MA (USA)\nWEEKL
 Y BIOENGINEERING COLLOQUIA SERIES\n(sandwiches served)\n\nAbstract: \nOur 
 lab is interested in the regulation of growth and metabolism by nutrients 
 and for some time we have focused on the mTOR pathway\, particularly the n
 utrient-sensing network anchored by mTOR Complex 1 (mTORC1). I will discus
 s our latest work on how mTORC1 senses cytosolic and lysosomal amino acids
  and the role selective autophagy plays. I will highlight our use of a met
 hod we developed to profile the metabolite and protein content of organell
 es to identify proteins that move on and off lysosomes in response to nutr
 ient conditions. I also may present our use of somatic cell genetics to id
 entify new components of metabolic pathways\, particularly in mitochondria
 l one-carbon metabolism.\n\n \nBio:\nDavid M. Sabatini is an American sci
 entist and Professor of Biology at the Massachusetts Institute of Technolo
 gy as well as a member of the Whitehead Institute for Biomedical Research.
  He has been an investigator of the Howard Hughes Medical Institute since 
 2008 and was elected to the National Academy of Sciences in 2016. He is kn
 own for his important contributions in the areas of cell signaling and can
 cer metabolism\, most notably the discovery and study of mTOR\, a protein 
 kinase that is an important regulator of cell and organismal growth that i
 s deregulated in cancer\, diabetes\, as well as the aging process.\n\nEduc
 ation:\nMD/PhD 1997\, Johns Hopkins School of Medicine\n\nResearch Summary
 :\nWe probe the basic mechanisms that regulate growth — the process wher
 eby cells and organisms accumulate mass and increase in size. The pathways
  that control growth are often hindered in human diseases like diabetes an
 d cancer. Our long-term goals are to identify and characterize these mecha
 nisms\, and to understand their roles in normal and diseased mammals.\n\n\
 nZoom link for attending remotely:  https://epfl.zoom.us/j/157047466\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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