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SUMMARY:Rational Vaccinology: In Pursuit of the Perfect Vaccine
DTSTART:20190408T121500
DTSTAMP:20260916T032117Z
UID:fdc8fc22805a0b7629a46c1c76cd2a6bb03e889231e770a76956a3ed
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Chad Mirkin\, Northwestern University\, Evanston. IL (US
 A)\nWEEKLY BIOENGINEERING COLLOQUIA SERIES\n(sandwiches served)\n\nAbstrac
 t: \nSpherical Nucleic Acids (SNAs) are an emergent therapeutic architectu
 re\, which consist of oligonucleotides radially conjugated to a nanopartic
 le core. This arrangement of DNA or RNA gives rise to unique properties no
 t observed with their linear counterparts\, such as rapid cellular uptake 
 and increased resistance to nuclease degradation. The emergent properties 
 of SNAs are revolutionizing the way we study\, track\, and treat disease a
 nd may help realize the promise of rational vaccinology: elucidating and l
 everaging the structure-activity relationships of SNAs to arrive at the mo
 st potent immunostimulatory construct. We are advancing this vision forwar
 d by treating solid tumors with immunostimulatory SNAs that activate an im
 mune response against cancer cells. This presentation will describe these 
 advancements and illustrate how rational vaccinology may improve human liv
 es.\n \nBio:\nDr. Chad A. Mirkin is the Director of the International Ins
 titute for Nanotechnology and the George B. Rathmann Prof. of Chemistry\, 
 Chemical and Biological Engineering\, Biomedical Engineering\, Materials S
 cience & Engineering\, and Medicine at Northwestern University.  He is a 
 chemist and a world-renowned nanoscience expert\, who is known for his dis
 covery and development of spherical nucleic acids (SNAs) and SNA-based bio
 detection and therapeutic schemes\, Dip-Pen Nanolithography (DPN) and rela
 ted cantilever-free nanopatterning methodologies\, On-Wire Lithography (OW
 L)\, and Co-Axial Lithography (COAL)\, and contributions to supramolecular
  chemistry and nanoparticle synthesis. He is the author of over 730 manusc
 ripts and over 1\,100 patent applications worldwide (over 300 issued)\, an
 d the founder of multiple companies\, including AuraSense\, Exicure\, TERA
 -print\, and CDJ Technologies. Mirkin has been recognized with over 130 na
 tional and international awards\, including the Wilhelm Exner Medal\, the 
 RUSNANOPRIZE\, the Dan David Prize\, and the inaugural Sackler Prize in Co
 nvergence Research. He was an eight-year Member of the President’s Counc
 il of Advisors on Science & Technology (Obama Administration)\, and one of
  very few scientists to be elected to all three US National Academies. He 
 is also a Fellow of the American Academy of Arts and Sciences\, the Americ
 an Chemical Society\, and the National Academy of Inventors\, among others
 . Mirkin has served on the Editorial Advisory Boards of over 20 scholarly 
 journals\, including JACS\, Angew. Chem.\, and Adv. Mater.\; at present\, 
 he is an Associate Editor of JACS. He is the founding editor of the journa
 l Small\, and he has co-edited multiple bestselling books. Mirkin holds a 
 B.S. degree from Dickinson College (1986) and a Ph.D. degree from the Penn
 . State Univ. (1989). He was an NSF Postdoctoral Fellow at the MIT prior t
 o becoming a professor at Northwestern Univ. in 1991.\n \n\nZoom link for
  attending remotely: https://epfl.zoom.us/j/256665847\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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