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SUMMARY:*CANCELLED* --- A Modular Receptor Platform to Expand the Sensing 
 Repertoire of Bacteria
DTSTART:20180604T121500
DTEND:20180604T131500
DTSTAMP:20260509T025329Z
UID:00db0712dd09aa09e7c14cc476f80653d76b384d23fd1db47ff05c5f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Jérôme Bonnet\, University of Montpellier (F)\nBIOENGI
 NEERING SEMINAR (cancelled)\n\nAbstract:\nEngineered bacteria promise to r
 evolutionize diagnostics\, therapeutics\, and environmental remediation. Y
 et\, many applications are precluded by the limited number of detectable s
 ignals. We designed a synthetic receptor platform enabling bacteria to res
 pond to novel ligands. These receptors are activated via ligand-induced di
 merization of a single-domain antibody fused to monomeric DNA-Binding Doma
 ins (split-DBDs). Once dimerized\, the transcriptional function of the DBD
  is restored. We highlight several receptors design principles\, show scal
 ability\, and downstream signal processing.  This modular platform could 
 be deployed into various hosts to detect ligands for which no receptor is 
 found in nature.\n\nBio:\nCurrently group leader at the Centre de Biochimi
 e Structurale\, University of Montpellier\, France\nfellow from the Stanfo
 rd Center on Longevity from 2009-2012\npost-doc in the Endy Lab at Stanfor
 d University from 2008 to 2013\n2007\, PhD in cell and molecular biology\,
  University of Montpellier (CRBM-CNRS UMR5237)\, France.\n2003\, MS in Bio
 logical science and health\, University of Montpellier.\n2001\, BS in Bioc
 hemistry\, University of Montpellier.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CANCELLED
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