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SUMMARY:The Role of Oxygen in Disease and Metabolism: Developing Hypoxia a
 s a Treatment for Mitochondrial Dysfunction
DTSTART:20180628T100000
DTEND:20180628T110000
DTSTAMP:20260916T203828Z
UID:f7514924b960835e6948b2c2e8694ebbe8e136b210fd0320a93cdd3c
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Isha H. Jain\, UCSF Sandler Faculty Fellow\, Dept. of Ph
 ysiology\, University of California\, San Francisco (USA)\nSEMINAR of the 
 LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANCE (LIMNA)\n\nAbstract
 :\nMitochondrial disease affects 1 in 4800 live births\, often leading to 
 death within the first few years of life. Currently\, there are no proven 
 therapies that work broadly for this class of disorders. We perform a geno
 me-wide screen and find that the cellular hypoxia response is protective a
 gainst mitochondrial dysfunction. Moreover\, chronic hypoxia extends the l
 ife of a mitochondrial mouse model of Complex 1 deficiency by five-fold. S
 tarting hypoxia therapy at a late-stage of disease can even reverse the ne
 urodegenerative phenotype and MRI-detectable lesions in this animal model.
  At the other extreme\, mild hyperoxia greatly exacerbates disease and lea
 ds to death within several days.\nThese findings have now led to a phase 1
  clinical trial in healthy volunteers\, with the ultimate goal of human tr
 anslation. We believe we have identified a new mode of treatment that will
  be broadly applicable to different forms of mitochondrial dysfunction\, r
 anging from rare inborn errors of metabolism to more common\, age-associat
 ed pathologies. We believe that “turning the oxygen dial” to low or hi
 gh oxygen will serve as a novel therapeutic for a range of conditions in t
 he coming years.\n \n\n(*) IMPORTANT NOTICE: All external participants ha
 ve to pass through SV Reception/Welcome Desk to be able to access to AI 11
 53. Contact person to call at arrival at SV Reception Desk: Administrative
  Assistant (ext. 3 95 22).
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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