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SUMMARY:Transcriptional control in time and space
DTSTART:20180710T090000
DTEND:20180710T103000
DTSTAMP:20260415T081431Z
UID:379ad1ae333d332d3dcbb5f4e4c2e53f12885a39fca794682a867e50
CATEGORIES:Conferences - Seminars
DESCRIPTION:Nadine L. Vastenhouw (MPI Molecular Cell Biology and Genetics 
 - Germany)\nUpon fertilization\, the genome of animal embryos is transcrip
 tionally inactive until the controlled onset of transcription during the m
 aternal-to-zygotic transition. We focus on this genome-wide onset of trans
 cription in zebrafish\, with the aim to understand how the transcriptional
  machinery and chromatin template are brought together in time and space t
 o robustly regulate transcription in hundreds of blastomeres during genome
  activation. We analyze transcriptional regulation quantitatively (quantif
 ication of repressors\, activators\, number of cells at genome activation\
 , transcripts) and at high resolution (imaging transcripts\, chromatin arc
 hitecture\, and transcriptional machinery at high resolution) in the conte
 xt of the embryo. This allows us to address questions about the timing of 
 transcription initiation during development\, synchrony between cells\, an
 d the function and establishment of nuclear architecture. I will present o
 ur latest results.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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