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SUMMARY:Mycolactone\, a pathogen-derived inhibitor of Sec61 with immunosup
 pressive properties
DTSTART:20180808T103000
DTEND:20180808T113000
DTSTAMP:20260506T045019Z
UID:192faaae99a7cd37db69962ab6c45ce2aa2428867ee28c2b98549f19
CATEGORIES:Conferences - Seminars
DESCRIPTION:Jean-David Morel\, Immunobiology of Infection Unit\, Institut 
 Pasteur\, Paris\, France\nSEMINAR of the LAUSANNE INTEGRATIVE METABOLISM a
 nd NUTRITION ALLIANCE (LIMNA)\n\nAbstract:\nMycolactone is a diffusible ma
 crolide produced by the human pathogen Mycobacterium ulcerans\, the causat
 ive agent of necrotic skin lesions called Buruli ulcers. In addition to di
 splaying cytotoxic properties locally\, mycolactone down-regulates the hos
 t immune responses. In vitro work had indicated that mycolactone blocks th
 e co-translational translocation of secretory proteins into the endoplasmi
 c reticulum (ER)\, leading to their cytosolic degradation by the ubiquitin
 :proteasome system. We demonstrated that mycolactone targets the alpha sub
 unit of the Sec61 translocon (Sec61α). Using quantitative proteomics\, we
  showed that Sec61 blockade impairs key immune processes\, such as antigen
  presentation by dendritic cells\, T cell activation and migration. These 
 global analyses also revealed that mycolactone-driven Sec61 blockade trigg
 ers ER stress responses\, eventually causing apoptotic cell death.\n \n\n
 (*) IMPORTANT NOTICE: All external participants have to pass through SV Re
 ception/Welcome Desk to be able to access to AI 1153. Contact person to ca
 ll at arrival at SV Reception Desk: Administrative Assistant (ext. 3 95 22
 ).\n 
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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