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SUMMARY:Neurodegeneration Seminar // Mechanistic link between LRRK2\, alph
 a-synuclein\, and lysosomal function
DTSTART:20181011T110000
DTEND:20181011T120000
DTSTAMP:20260427T204615Z
UID:33cdd49d2d42ff96d79195598bb84aa22eedb159c958e4fe5759c141
CATEGORIES:Conferences - Seminars
DESCRIPTION:Lina Mastrangelo\, PhD\, Sanford Consortium for Regenerative M
 edicine [SCRM]\, La Jolla\, CA\, USA\nRecent advances in the genetics and 
 developmental biology of Parkinson’s Disease (PD) have greatly expanded 
 our understanding of this common neurodegenerative disorder and have begun
  to identify desperately needed new approaches to therapy. In this talk I 
 will discuss the potential direct role of the mutated gene encoding leucin
 e-rich repeat kinase 2 (LRRK2) in dysregulating lysosomal pathways and in 
 causing a pathologically synergistic interaction between LRRK2 and PD risk
  factors such as the aberrant expression of alpha-synuclein. Our data supp
 ort a role for impaired autophagy in PD with cross-talk between macroautop
 hagy and chaperone-mediated autophagy. These findings may help to clarify 
 how interactions between LRRK2\, alpha-synuclein\, and autophagy processes
  contribute to the pathogenesis of Parkinson’s Disease.\n 
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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