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SUMMARY:A Silicon-Based Platform for Biochemical Sensing
DTSTART:20180626T133000
DTEND:20180626T143000
DTSTAMP:20260502T134705Z
UID:a61020134e415a1d42585d324d38193dfbd10e63098a49eeb47381cb
CATEGORIES:Conferences - Seminars
DESCRIPTION:Mathias Wipf\, Ph.D.\, EMPA\, Dübendorf (CH)\nBIOENGINEERING 
 SEMINAR\n\nAbstract:\nPotentiometric sensors based on ion-sensitive field-
 effect transistors have attracted a lot of interest due to their potentia
 l to be integrated in sensor systems for the analysis of multiple biochem
 ical parameters at low dimensions and cost. The specific sensing of ions
  and proteins over large concentration ranges has been reported using var
 ious detection schemes. However\, the commercial success of micro- and n
 anoscale potentiometric sensors has not exceeded pH measurements. We stud
 ied the intrinsic limitations of this technology\, such as signal-to-noi
 se ratio\, Debye screening\, and competing surface reactions\, and presen
 t methods how to address these. We have studied the label-free detection
  of various metal ions\, such as Na+\, Ca2+ and Cu2+\, and proteins using
  silicon nanowire field-effect transistors. Further\, we have demonstrate
 d methods to quantify proteins in blood and serum at high specificity us
 ing enzyme-linked immunosorbent assays in combination with an electrical 
 readout. Currently we are working on the commercialization of solid-stat
 e potentiometric sensors for the use in point-of-care diagnostics.\n\nBio:
 \nMathias Wipf obtained his Master degree in nanoscience at the Universit
 y of Basel\, where he completed his Ph.D. in physics in Prof. Christian 
 Schönenberger’s group\, studying biosensors based on silicon nanowires
  for the detection of ions and proteins. Afterwards he accepted a resear
 ch position as postdoc in Prof. Mark Reed’s group at the department of 
 electrical engineering at Yale University\, where he worked on electrica
 l readout methods of immunoassays. In 2016\, he joined the Silicon Valley
  startup Avails Medical\, Inc.\, where he is working on the development 
 of an in vitro diagnostic test for the detection of bacterial infections\
 , which allows the quantification of bacteria and antibiotic susceptibil
 ity testing in blood samples. He recently founded the company MOMM Diagn
 ostics GmbH in Basel\, for the development of a point-of-care test for pr
 eeclampsia\, one of the most common pregnancy complications. In a resear
 ch collaboration with Prof. Michel Calame at EMPA\, Switzerland\, he is c
 urrently leading the biosensor team in the laboratory “Transport at na
 noscale interfaces”\, working on new methods for label-free chemical- a
 nd biochemical sensing.\n \n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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