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SUMMARY:Chlamydia is a Master Cell Biologist: The Secret Lives of Intracel
 lular Pathogens
DTSTART:20180717T121500
DTSTAMP:20260527T190451Z
UID:a79a80442ac785e18a50b675c3f8c1e8195c9a44c8e3bf5a96ab0666
CATEGORIES:Conferences - Seminars
DESCRIPTION:Joanne Engel\, Director\, Microbial Pathogenesis and Host Defe
 nse Program\, University of California\, San Francisco (UCSF)\nChlamydia t
 rachomatis is a leading cause of genital and ocular infections for which n
 o vaccine exists. Upon entry into host cells\, C. trachomatis resides with
 in a membrane-bound compartment — the inclusion — and secretes inclusi
 on membrane proteins (Incs) that are thought to modulate the host-bacteriu
 m Interface. In the absence\, until recently\, of being able to geneticall
 y manipulate Chlamydia\, we used high through-put affinity purification/ma
 ss spectroscopy to identify potential host binding partners for the Incs t
 o infer and explore their function.  We have identified high confidence h
 ost protein interactors for ~2/3 of the Incs and will discuss potential in
 teractions with retromer-dependent vesicular trafficking and dynactin func
 tion at the centrosome. This study demonstrates the value of proteomics in
  unveiling hos-tpathogen interactions in genetically challenging microbes.
 \n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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