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SUMMARY:Dissecting Tumour-induced Signalling Pathways Driving Energy Wasti
 ng
DTSTART:20180809T100000
DTEND:20180809T110000
DTSTAMP:20260408T065706Z
UID:c40459d567e0182ca1e7447ec33d0129c92ea113f9249f0ebe073928
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Serkan KIR\, Department of Molecular Biology and Genetic
 s\, Koç University\, Istanbul (Turkey)\nSEMINAR of the LAUSANNE INTEGRATI
 VE METABOLISM and NUTRITION ALLIANCE (LIMNA)\n\nAbstract:\nNearly half of 
 all cancer patients suffer from cachexia\, a wasting syndrome associated w
 ith elevated energy expenditure and the loss of adipose and skeletal muscl
 e tissues. With no effective therapy against it\, cancer cachexia has rema
 ined a devastating problem that reduces quality of life and limits therapy
 . Research in my laboratory aims to dissect the molecular mechanisms behin
 d tumour signalling to adipose and muscle tissues and identify novel molec
 ular targets for anti-cachexia therapy. Our work demonstrated that the tum
 our-derived factor Parathyroid hormone-related protein (PTHrP) triggers th
 e browning of white fat tissue and promotes protein catabolism in skeletal
  muscle. Circulating PTHrP correlates with a greater degree of cachexia in
  cancer patients and the neutralization of this factor in tumour-bearing m
 ice blocks adipose tissue browning and energy wasting while preserving mus
 cle mass and strength. Recently\, we have also discovered that Oncostatin 
 M (OSM)\, another tumour-derived factor\, induces atrophy in cultured musc
 le cells. OSM mediates a novel tumour-induced signalling pathway which app
 ears to target both adipose and muscle tissues. We continue addressing the
  importance of PTHrP and OSM signalling in the aetiology of cancer cachexi
 a with the overarching goal of studying therapeutic blockade of these path
 ways\, which may prevent wasting in cancer patients.\n \n\n(*) IMPORTANT 
 NOTICE: All external participants have to pass through SV Reception/Welcom
 e Desk to be able to access to AI 1153. Contact person to call at arrival 
 at SV Reception Desk: Administrative Assistant (ext. 3 95 22).\n\n 
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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