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SUMMARY:Vitamin and Mineral Inadequacy Accelerates Aging-Associated Diseas
 es 
DTSTART:20120521T100000
DTEND:20120521T110000
DTSTAMP:20260407T105818Z
UID:d0a316d3cdb6172ee0ef313cf99a408948ef502c8fe0e12f784d6aff
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Bruce N. AMES\nSenior Scientist\, Nutrition and Metabolism
  Center\nChildren’s Hospital Oakland Research Institute\, Oakland\, Cali
 fornia\;\nProfessor Emeritus\nUniversity of California\, Berkeley\, USA\nh
 ttp://www.bruceames.org/\nI posited\, and have buttressed\, “triage theo
 ry”: metabolism responds to moderate deficiency of an essential vitamin 
 or mineral (V/M) so that the scarce V/M is preferentially retained by V/M-
 dependent proteins necessary for short-term survival and reproduction.  I
 n contrast\, proteins needed for long term health\, which I term “longev
 ity proteins” because they defend against the diseases associated with a
 ging\, lose the V/M and are disabled. Most of the world’s population\, i
 ncluding that of the U.S.\, are moderately deficient in one or more of the
  ~30 essential V/Ms. Moreover\, since the damage from moderate deficiency 
 is insidious\, its importance for long-term health is not being appreciate
 d. Strong support for triage theory comes from Joyce McCann’s analyses o
 f the literature on proteins dependent on vitamin K and on selenium. Both 
 have built into metabolism this trade-off between short-term survival and 
 long-term health and each uses a different mechanism to accomplish this en
 d. Theory and evidence suggest that this metabolic trade-off accelerates a
 ging-associated diseases\, such as cancer\, cognitive decline\, and cardio
 vascular disease.  Importantly\, by the official U.S. Institute of Medici
 ne measure of inadequacy\, the EAR (Estimated Average Requirement\; the RD
 A is set at 2 SD above the EAR)\, most of the U.S. population is below the
  EAR for one or more V/M. Taking these long-term triage effects into accou
 nt in setting EARs could lead to numerous changes. We have calculated from
  the NHANES database that the percentages of the U.S. population that are 
 below the EAR are: magnesium 56%\; zinc 12%\; iron 16% of menstruating wom
 en\; vitamin B6 49% of elderly women\; folate 16% of adult women. The U.S.
  population also has very low intake of vitamin D\, calcium\, potassium\, 
 omega-3 fatty acids\, vitamin K\, and probably others\, and this is especi
 ally true for children\, adolescents\, elders\, and the obese. Longevity p
 roteins\, about half of those studied\, indicate a mechanism that could be
  used for prevention by monitoring for insidious damage and suggest the ex
 istence of an undiscovered class of longevity V/Ms\, which we are discover
 ing. Our Choribar (V/M-dense\, low-calorie\, high-fiber\, fruit-based) mar
 kedly improves metabolism in many human trials.
LOCATION:SV 1717A http://plan.epfl.ch/?room=SV%201717A&lang=fr
STATUS:CONFIRMED
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