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SUMMARY:BMI SEMINAR // Transcriptional regulation of survival of dopaminer
 gic neurons and its implication in Parkinson’s disease
DTSTART:20181024T121500
DTEND:20181024T131500
DTSTAMP:20260916T220421Z
UID:3a431e4c36c41f479dbe3ae3ae1b9b3f58525da5072bb8532cc02b3a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Emi Nagoshi\, Behavioral neuroscience & neurodegeneration\, De
 pt. Of Genetics and Evolution\, University of Geneva\, Switzerland\nParkin
 son’s disease (PD) is the most common movement disorder characterized by
  the progressive loss of dopaminergic cells in the substantia nigra pars c
 ompacta. Accumulating evidence indicates that the interactions between gen
 etic and environmental factors cause PD. Although several monogenic mutati
 ons linked to rare familial PD have been identified\, other genetic determ
 inants causative for sporadic PD\, which account for more than 80% of case
 s\, are largely unknown.\n \nOur lab has recently shown that two transcri
 ption factor genes\, Fer2 (p48 related-2) and dfoxo\, play partly overlapp
 ing roles in the survival of a subclass DA neurons important for locomotio
 n in flies. Loss-of-function of either gene causes cellular and behavioral
  phenotypes reminiscent of PD. Genetically\, Fer2 and dfoxo act in paralle
 l pathways to protect DA neurons from different stressors\, but share comm
 on downstream processes leading to the regulation of mitochondrial biology
  and autophagy. These results add evidence to the complex gene-environment
  interactions underlying dopaminergic neurodegeneration and suggest that F
 er2 and dfoxo mutants offer new tools to study pathogenesis of sporadic PD
 .\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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