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SUMMARY:IGM Colloquium: Cybergenetics: Rationally-designed genetic control
  systems
DTSTART:20181030T121500
DTEND:20181030T131500
DTSTAMP:20260407T025742Z
UID:5ee0fdaf511c2f956d5afb4c32815bc8c72b348c535db3cedcad5df3
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Mustafa Khammash ETH Zürich\, Control Theory and System
 s Biology Laboratory \nAbstract:\nHumans have been influencing the DNA of 
 plants and animals for thousands of years through selective breeding. Yet 
 it is only over the last 3 decades or so that we have gained the ability t
 o manipulate the DNA itself and directly alter its sequences through the m
 odern tools of genetic engineering. This has revolutionized biotechnology 
 and ushered in the era of synthetic biology. Among the possible applicatio
 ns enabled by synthetic biology is the design and engineering of feedback 
 control systems that act at the molecular scale in real-time to steer the 
 dynamic behavior of living cells. Here I will present our theoretical fram
 ework for the design and synthesis of such control systems\, and will disc
 uss the main challenges in their practical implementation. I will then pre
 sent the first designer gene network that attains integral feedback in a l
 iving cell and demonstrate its tunability and disturbance rejection proper
 ties. A growth control application shows the inherent capacity of this int
 egral feedback control system to deliver robustness\, and highlights its p
 otential use as a universal controller for regulation of biological variab
 les in arbitrary networks. Finally\, I will discuss the potential impact o
 f biomolecular control systems in industrial biotechnology and medical the
 rapy and bring attention to the opportunities that exist for control theor
 ists to advance this young area of research.\n\nBio:\nMustafa Khammash is 
 the Professor for Control Theory and Systems Biology at the Department of 
 Biosystems Science and Engineering at ETH Zurich\, Switzerland. He works i
 n the areas of control theory\, systems biology\, and synthetic biology. H
 is lab develops theoretical\, computational\, and experimental methods aim
 ed at understanding the role of dynamics\, feedback\, and randomness in bi
 ology. He is currently developing new theoretical and experimental approac
 hes for the design of biomolecular control systems and for their realizati
 on in living cells.\nProf. Khammash received his B.S. degree from Texas A&
 M University in 1986 and his PhD from Rice University in 1990\, both in el
 ectrical engineering. In 1990\, he joined the engineering faculty of Iowa 
 State University\, where he created the Dynamics and Control Program and l
 ed the control group until 2002. He then joined the engineering faculty at
  the University of California\, Santa Barbara (UCSB)\, where he was Direct
 or of the Center for Control\, Dynamical Systems and Computation (CCDC) un
 til 2011 when he joined ETH Zurich. He is a Fellow of the IEEE\, IFAC\, an
 d the Japan Society for the Promotion of Science (JSPS).
LOCATION:MED 0 1418 https://plan.epfl.ch/?room==MED%200%201418
STATUS:CONFIRMED
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