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SUMMARY:The role of centrioles and cilia in asymmetric neural stem cell di
 vision
DTSTART:20181019T140000
DTEND:20181019T150000
DTSTAMP:20260916T203758Z
UID:5ae21576de47a8e4bdc25956ef1376418f331c3f9a3ca9d2bb26c669
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Judith Paridaen\; Junior Principal Investigator\; European
  Research Institute for the Biology of Ageing (ERIBA)/UMCG\nControl of ste
 m cell division modes is important to ensure generation of properly sized 
 tissues during development as well as adult tissue homeostasis and repair.
  Stem cells undergo repeated cell divisions in which they produce daughter
  cells that either mature or remain stem cells. Surprisingly\, the number 
 and type of produced daughter cells vary between individual stem cells. To
  understand this heterogeneity better\, my group is investigating how stem
  cells\, and in particular neural stem and progenitors\, are regulated at 
 the single-cell level.\n\nAsymmetric stem cell divisions balance stem cell
  self-renewal and differentiation as the mother cell gives rise to two une
 qual daughter cells. These different fates can be induced by unequal segre
 gation of organelles and cell fate determinants between daughter cells. I 
 previously showed that membrane derived from primary cilia\, which are key
  sensory organelles\, is retained by one of the centrosomes throughout mit
 osis by neural stem cells. This ciliary membrane remnant is inherited main
 ly by the stem cell daughter cell that re-establishes a cilium before its 
 sister cell. We propose that the observed asynchronous ciliogenesis after 
 mitosis differentially exposes daughter cells to proliferative signals and
  influences downstream cell fate decisions.\n\nMy research group is curren
 tly developing and applying state-of-the-art single-cell analyses\, time-l
 apse imaging and genetic manipulations to investigate stem cell decisions 
 in zebrafish and mouse embryos. These approaches are complemented with com
 putational modelling to predict the effects of gene expression and signall
 ing activity changes on stem cell division outcomes. Unravelling the mecha
 nisms that regulate stem cell decisions could provide new insights and mea
 ns to manipulate stem cells to aid tissue regeneration and healthy ageing.
 \n\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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