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SUMMARY:Innate DNA sensing through the cGAS-STING system - Blurring the bo
 undary between PAMP and DAMP
DTSTART:20181217T121500
DTEND:20181217T131500
DTSTAMP:20260511T041353Z
UID:9c8bee8bdd8ee462d27679928faef0c85d386beb557169bf071a7b2f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Andrea Ablasser\nAbstract :\nThe life of any organism depen
 ds on the ability of cells to accurately recognize and eliminate harmful m
 icrobes. In order to detect the immense repertoire of pathogenic entities\
 , the innate immune system of mammals has evolved a range of distinct sens
 ing strategies. One major mechanism is based on the recognition of microbi
 al DNA - an invariant and highly immunogenic pathogen-associated molecular
  pattern (PAMP). Host cells\, however\, contain abundant sources of self-D
 NA. In the context of cellular damage or metabolic derangement\, “out-of
 -the-context” self-DNA can elicit potentially damaging inflammatory resp
 onses\, thus serving as a potent danger-associated molecular pattern (DAMP
 ).\nIn my laboratory at EPFL\, we study primarily the so-called cGAS-STING
  system - an evolutionary highly conserved innate DNA sensing system. On D
 NA binding\, cGAS is activated to produce a second messenger cyclic dinucl
 eotide (cyclic GMP-AMP)\, which stimulates the adaptor protein STING to in
 duce innate immune responses. While this process was originally discovered
  as a crucial component of immune defense against pathogens\, recent work 
 has elucidated a pathogenic role for innate DNA sensing in a variety of st
 erile inflammatory diseases. In this seminar I will give an overview of ou
 r contributions to the understanding of the molecular mechanisms underlyin
 g innate DNA recognition and highlight how such knowledge may be leveraged
  to develop innovative new medicines.\n\nSelected References:\nHaag et al.
 \, Nature 2018 Jul\;559(7713):269-273.\nGulen et al.\, Nature Communicatio
 ns 2017 Sep 5\;8(1):427.\nGlück et al.\, Nature Cell Biology 2017 Sep\;19
 (9):1061-1070.\nWassermann et al.\, Cell Host & Microbe 2015 Jun 10\;17(6)
 :799-810.\nAblasser* et al.\, Nature 2013 Jun 20\;498(7454):380-4.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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