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SUMMARY:The CRL4 ubiquitin ligase: at the intersection of genome stability
  and drug discover
DTSTART:20181023T161500
DTEND:20181023T170000
DTSTAMP:20260916T210801Z
UID:67870c8eb2003f2cd61ac3ff8ef3d80d2a4668050543058319ebc01b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Nicolas Thomä\, FMI Basel\, Switzerland\nMy research in
 terests are in understanding the molecular basis of genome maintenance. 
  Our genetic information is constantly protected against endogenous and 
 exogenous attack by enzymatic maintenance that repairs mutations and prev
 ents duplication or deletion events. On a biomedical level\, defects in t
 hese pathways are frequently associated with cancer. I focus on protein c
 omplexes at the interface of DNA repair\, replication\, ubiquitin biolog
 y and chromatin. My laboratory has set out to combine structural biology\,
  cell biology and complex biochemical in vitro reconstitutions to addr
 ess the molecular workings of these chromatin-bound complex assemblies. 
 Recently\, we extended our focus to understanding how small molecules can 
 reprogram the ubiquitin system for therapeutic intervention.
LOCATION:BCH 2201 https://plan.epfl.ch/?room==BCH%202201
STATUS:CONFIRMED
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