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SUMMARY:Trigger waves in cell signalling
DTSTART:20190326T161500
DTSTAMP:20260501T144246Z
UID:3cbd6d64c649bf78c6525c21fbea846534558975ee0d71c98c467569
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. James Ferrell\, Prof. of Chemical and Systems Biology\, 
 Professor of Biochemistry\, Stanford University. US. \nThe Ferrell lab st
 udies signal transduction and cell cycle regulation\, mainly focusing the 
 spatial and temporal regulation of mitotic entry and exit. They explore ho
 w the individual proteins that regulate these processes work together in 
 circuits\, generating reliable systems-level behaviors\, by using quantita
 tive experimental approaches\, modeling\, and theory. Much of their work 
 make use of Xenopus laevis oocytes\, eggs\, embryos\, and extracts\, as 
 well as mammalian cell lines.\n\nAbout the talk\n\nFerrell’s group has b
 een exploring the question of how regulatory signals spread through cells.
  By using as model system Xenopus egg extracts\, the lab demonstrated that
  Cdk1 activity - which makes mitosis happen - and caspase-3/7 - which make
 s apoptosis happen - spread through the cytoplasm via what are termed trig
 ger waves. There is good evidence that they do also in intact Xenopus eggs
 . Trigger waves require only three basic ingredients (positive feedback in
  the biochemical reactions\, a mechanism for local spatial coupling\, and 
 a localized initiation point). The Ferrell lab suspects that they will pro
 ve to be widespread in the coordination of signaling in large cells and ti
 ssues.
LOCATION:SV.1717
STATUS:CONFIRMED
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