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SUMMARY:Turning Powder into Single Crystals:  Application of 3D Electron D
 iffraction to Chemical Crystallography
DTSTART:20181122T171500
DTEND:20181122T181500
DTSTAMP:20260414T181438Z
UID:679ae409b9ff04e582c42bad0644f48827aeb11ec4731263f461ab56
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Tim Grüne\nPSI\, Villigen\nThe use of electrons for cryst
 allography was discovered only a few decades after the work of von Laue a
 nd the Braggs. Unlike X-ray crystallography\, inorganic\, organic\, and b
 iological electron crystallography were developed rather independently. U
 ntil about 2000\, electron crystallography in all three fields was essent
 ially two dimensional: mostly thin layers were investigated. This changed
  with the work of the groups of Ute Kolb (Uni Mainz) and of Xiaodong Zou/
 Sven Hovmoeller (Uni Stockholm)\, who produced first results in 3D electro
 n\ncrystallography based on the classial rotation method. This and similar
  developments have their origin in the material sciences\, blended with e
 lements from the rotation method.\n\nSingle Crystal 3D Electron crystallo
 graphy of organic and macromolecular compounds benefits greatly from the 
 developments in X-ray crystallography.  E.g. profile fitting and data sc
 aling are concepts that are unusual in the crystallography of material sc
 ience. For electron diffraction\, these concepts reduce the impact of dyn
 amic scattering. My work has focused on the methods development of electr
 on crystallography with the perspective from structural chemistry. Modern
  X-ray integration software like XDS\, SAINT\, and DIALS bring new aspect
 s into the field of electron crystallography. These programs produce reli
 able structures from crystals that are minute compared to samples used in
  X-ray crystallography.  This talk will present the results of the nanoA
 rgovia project "A3EDPI". We mounted a DECTRIS EIGER detector onto a trans
 mission\nelectron microscope and ensured fast and reliable determination o
 f those parameters required for data processing with XDS. With this setup
  we created a prototype electron diffractometer. We determined the new st
 ructure of a methylene blue derivative\, and extracted the structure of p
 aracetamol out of the powder of Grippostad\, taken to the TEM directly fr
 om the pharmacy. I will also present two newly developed types of sample 
 support that overcome the missing wedge problem.
LOCATION:BCH 2201 https://plan.epfl.ch/?room==BCH%202201
STATUS:CONFIRMED
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