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SUMMARY:Activation of transcription factor Nrf2 as a strategy to restore t
 he cellular redox and protein homeostasis
DTSTART:20181204T161500
DTEND:20181204T171500
DTSTAMP:20260427T230458Z
UID:c0d7002be2783c6ba14869618af8c9ed7e731f4e42d61694f8f22f81
CATEGORIES:Conferences - Seminars
DESCRIPTION:Albena T. Dinkova-Kostova\nDisrupted redox and protein homeost
 asis and chronic inflammation are characteristic features of most human pa
 thologies. The transcription factor Nrf2 regulates the expression of large
  networks of genes encoding proteins that provide powerful and long-lastin
 g protection against damage by oxidants and pro-inflammatory agents. Most 
 pharmacological activators of Nrf2 (termed inducers) are electrophiles th
 at target discreet highly reactive sensor cysteines within Kelch-like ECH-
 associated protein 1 (Keap1)\, the main negative regulator of Nrf2\, impai
 ring the repressor function of Keap1\, and allowing for Nrf2 accumulation 
 and enhanced transcription of its target genes. The Nrf2 regulatory netwo
 rk includes drug metabolizing\, antioxidant\, anti-inflammatory and metabo
 lic enzymes\, proteasomal subunits and autophagy-related proteins\, and th
 us has a critical role in the maintenance of the cellular redox and protei
 n homeostasis\, and in the resolution of inflammation. Pharmacological Nrf
 2 activation with electrophilic inducers\, some of which are in clinical 
 trials\, shows multiple beneficial effects in cell culture and animal mod
 els of epilepsy\, Parkinson’s disease\, and Huntington’s disease.
LOCATION:BCH 2201 https://plan.epfl.ch/?room==BCH%202201
STATUS:CONFIRMED
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