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SUMMARY:Mechanical Force Mediated 3D Organogenesis Withstanding Gravity Co
 ntrolled by YAP
DTSTART:20181122T101500
DTSTAMP:20260408T005545Z
UID:bd1aefd441800328b5ef4ba87b2ec01372330dc12fe8540a433754e8
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Makoto Furutani-Seiki\, Yamaguchi University (JPN)\n \n
 BIOENGINEERING SEMINAR\n\nAbstract: \nCells of terrestrial animals are con
 stantly exposed to external forces including gravity. However\, the comple
 x 3D structure of the body and its organs form without being flattened. A 
 century ago\, the mathematical biologist D’Arcy Thompson predicted in 
 ‘On Growth and Form’ that terrestrial animal body shapes are entirely 
 conditioned by gravity\, but the prediction remained to be proved due to t
 he lack of an appropriate animal model. I will present a new mechanism of 
 morphogenesis which ensures the generation of vertebrate 3D body and organ
  shape that can withstand gravity identified by the analysis of medaka fis
 h mutant “hirame” (Porazinski et al.\, Nature 2015). Its molecular mec
 hanism regulated by the transcriptional activator YAP is involved in the b
 i-directional mechanical interactions between cells and extracellular matr
 ix (ECM)\, called mechano-homeostasis: tissue stem cells differentiate acc
 ording to ECM stiffness and conversely\, differentiated cells maintain the
 ir identify by controlling ECM stiffness (Asaoka & Furutani-Seiki\, Curr O
 pin Cell Biol\, 2017). Our finding also lead to the identification of YAP 
 as a gravity response gene. We now plan to carry out experiments in space 
 to prove this model.\n\nBio:\nMakoto Furutani-Seiki is a Professor of Syst
 ems Biochemistry at Yamaguchi University School of Medicine\, Japan\, and 
 a visiting Associate Professor at the University of Bath\, UK. Dr. Furutan
 i-Seiki is an M.D. and obtained his Ph.D. in Immunology from the Universit
 y of Tokyo\, supervised by Tomio Tada (1989). He was a postdoc in Janni N
 üsslein-Volhard’s lab at Max-Planck-Institute in Tübingen (1992-1997)\
 , after which he conducted a genome-wide mutagenesis screen using medaka f
 ish as a group leader of the Kondoh Differentiation Signaling ERATO projec
 t (Japan Science and Technology Agency\, 1998-2007). He then moved to Univ
 ersity of Bath\, UK\, Centre for Regenerative Medicine as a MRC Senior Res
 earch Fellow\, and continues his research at Yamaguchi University School o
 f Medicine\, Japan.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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