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SUMMARY:CMOS Microelectronics for DNA detection using Ion-Sensitive Field 
 Effect Transistors
DTSTART:20190701T101500
DTEND:20190701T113000
DTSTAMP:20260407T064028Z
UID:654a7cf348a098b43fcec99ebd46850e7528e03af422295330146eb1
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Dr. Pantelis Georgiou\nImperial College London\nInstitut
 e of Microengineering - Distinguished Lecture\n\nCampus Lausanne SV 1717 (
 live)\nCampus Microcity MC B0 302 (video)\nZoom Live Stream: https://epfl.
 zoom.us/j/983964754 \n\nAbstract: In the last decade\, we have seen a conv
 ergence of microelectronics into the world of healthcare providing novel s
 olutions for early detection\, diagnosis and therapy of disease. This has 
 been made possible due to the emergence of CMOS technology\, allowing fabr
 ication of advanced systems with complete integration of sensors\, instrum
 entation and processing\, enabling design of miniaturised medical devices 
 which operate with low-power. This has been specifically beneficial for th
 e application areas of DNA based diagnostics and full genome sequencing\, 
 where the implementation of chemical sensors known as Ion-Sensitive Field 
 Effect Transistors (ISFETs) directly in CMOS has enabled the design of lar
 ge-scale arrays of millions of sensors that can conduct in-parallel detect
 ion of DNA. Furthermore\, the scaling of CMOS with Moore’s law and the i
 ntegration capability with microfluidics has enabled commercial efforts to
  make full genome sequencing affordable and therefore deployable in hospit
 als and research labs.\n \nIn this talk\, I present how my lab is advanci
 ng the areas of DNA detection and rapid diagnostics through the design of 
 CMOS based Lab-on-Chip systems using ISFETs. I will first introduce the fu
 ndamentals and physical properties of DNA as a target molecule and how it 
 can be detected using different modalities through the use of CMOS technol
 ogy. I will then present methods of design of ISFET sensors and instrument
 ation in CMOS\, in addition to the challenges and limitations that exist f
 or fabrication\, providing solutions to allow design of large-scale ISFET 
 arrays for real-time DNA amplification and detection systems. I will concl
 ude with the presentation of state-of-the-art CMOS systems that are curren
 tly being used for genomics and point-of-care diagnostics\, and the result
 s of our latest fabricated multi-sensor CMOS platform for rapid screening 
 of infectious disease and management of antimicrobial resistance.\n\nBio: 
 Pantelis Georgiou currently holds the position of Reader (Associate Profes
 sor) at Imperial College London within the Department of Electrical and El
 ectronic Engineering. He is the head of the Bio-inspired Metabolic Technol
 ogy Laboratory in the Centre for Bio-Inspired Technology\; a multi-discipl
 inary group that invents\, develops and demonstrates advanced micro-device
 s to meet global challenges in biomedical science and healthcare. His rese
 arch includes ultra-low power micro-electronics\, bio-inspired circuits an
 d systems\, lab-on-chip technology and application of micro-electronic tec
 hnology to create novel medical devices. Application areas of his research
  include new technologies for treatment of diabetes such as the artificial
  pancreas\, novel Lab-on-Chip technology for genomics and diagnostics targ
 eted towards infectious disease and antimicrobial resistance (AMR)\, and w
 earable technologies for rehabilitation of chronic conditions.\n \nDr. Ge
 orgiou graduated with a 1st Class Honours MEng Degree in Electrical and El
 ectronic Engineering in 2004 and Ph.D. degree in 2008 both from Imperial C
 ollege London. He then joined the Institute of Biomedical Engineering as R
 esearch Associate until 2010\, when he was appointed Head of the Bio-inspi
 red Metabolic Technology Laboratory. In 2011\, he joined the Department of
  Electrical & Electronic Engineering\, where he currently holds an academi
 c faculty position. He conducted pioneering work on the silicon beta cell 
 and is now leading the project forward to the development of the first bio
 -inspired artificial pancreas for treatment of Type I diabetes. In additio
 n to this\, he made significant contributions to the development of integr
 ated chemical-sensing systems in CMOS. He has pioneered the development of
  the Ion-Sensitive Field Effect Transistor\, an integrated pH sensor which
  is currently being used in next generation DNA sequencing machines\, demo
 nstrating for the first time its use in low-power weak-inversion\, and its
  capability in a multimodal sensing array for Lab-on-Chip applications. Dr
 . Georgiou is a senior member of the IEEE and IET and serves on the BioCAS
  and Sensory Systems technical committees of the IEEE CAS Society. He is a
 n associate editor of the IEEE Sensors and TBioCAS journals. He is also th
 e CAS representative on the IEEE sensors council. In 2013 he was awarded t
 he IET Mike Sergeant Achievement Medal for his outstanding contributions t
 o engineering and development of the bio-inspired artificial pancreas. In 
 2017\, he was also awarded the IEEE Sensors Council Technical Achievement 
 award. He is an IEEE Distinguished Lecturer in Circuits and Systems.\n\nNo
 te: The Seminar Series is eligible for ECTS credits in the EDMI doctoral p
 rogram. 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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