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PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Physics of epithelial flows and folds
DTSTART:20181203T140000
DTSTAMP:20261001T014154Z
UID:2015092f2937786e6b09f3128fe69ad381193cfe94989378fbc8fd4c
CATEGORIES:Conferences - Seminars
DESCRIPTION:Guillaume Salbreux\nThe shape of a biological tissue is determ
 ined by mechanical stresses acting within the tissue cells. During embryon
 ic morphogenesis\, forces generated in the actomyosin cytoskeleton in the 
 cell of epithelia result in cell deformation\, cell rearrangements\, and 3
 D bending of the epithelium. To understand tissue morphogenesis\, force ge
 neration at the cellular scale must be related to flows and deformation oc
 curring at the tissue scale. Here I will discuss how this relation can be 
 captured by a 3D vertex model or by a continuum theory of active surfaces 
 to understand epithelial fold formation during embryonic development. Usin
 g this framework\, one finds that two different mechanisms\, basal relaxat
 ion and lateral constriction\, can account for fold formation in the Droso
 phila wing disc. I will also discuss how planar tissue flows are related t
 o cell shape changes and cell division\, and show how the growth of the Dr
 osophila histoblast nests can be decomposed into basic cellular events.
LOCATION:BSP 233 https://plan.epfl.ch/?room==BSP%20233
STATUS:CONFIRMED
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