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SUMMARY:Physics of epithelial flows and folds
DTSTART:20181203T140000
DTSTAMP:20260930T223223Z
UID:69d6357d2c19eb095147a781097edd00982338844dab6502577bcd5f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Guillaume Salbreux\, The Francis Crick Institute\, London\nThe
  shape of a biological tissue is determined by mechanical stresses acting 
 within the tissue cells. During embryonic morphogenesis\, forces generated
  in the\nactomyosin cytoskeleton in the cell of epithelia result in cell d
 eformation\, cell rearrangements\, and 3D bending of the epithelium. To un
 derstand tissue morphogenesis\, force generation at the cellular scale mus
 t be related to flows and deformation occurring at the tissue scale. Here 
 I will discuss how this relation can be captured by a 3D vertex model or b
 y a continuum theory of active surfaces to understand epithelial fold form
 ation during embryonic development. Using this framework\, one finds that 
 two different mechanisms\, basal relaxation and lateral constriction\, can
  account for fold formation in the Drosophila wing disc. I will also discu
 ss how planar tissue flows are related to cell shape changes and cell divi
 sion\, and show how the growth of the Drosophila histoblast nests can be d
 ecomposed into basic cellular events.
LOCATION:BSP 233 https://plan.epfl.ch/?room==BSP%20233
STATUS:CONFIRMED
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