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SUMMARY:In situ analyses of protein structural changes in health and disea
 se
DTSTART:20181217T160000
DTEND:20181217T170000
DTSTAMP:20260920T060456Z
UID:532c95a2a23d537ca83db71dbc7047ca46a3969f9aa9b64f20419bd9
CATEGORIES:Conferences - Seminars
DESCRIPTION:Professor Paola Picotti\nProtein conformational changes induce
 d by external perturbations or internal cues can profoundly influence prot
 ein activity and thus modulate cellular physiology. Mass spectrometry (MS)
 -based proteomic techniques are routinely used to measure changes in prote
 in abundance\, post-translational modification and protein interactors\, b
 ut much less is known about alterations in protein structures.\nProf. Paol
 a Picotti will present a recently developed structural proteomics method t
 hat enables analysis of protein structural changes on a proteome-wide scal
 e and directly in complex biological extracts. She will describe how the n
 ew approach is used to study the molecular bases of protein aggregation di
 seases and shed light on the in situ structures of aggregation-prone prote
 ins. Further\, she will present an application of the approach to the iden
 tification of protein-small molecule interactions\, including allosteric a
 nd drug-target interactions. Last\, Prof. Paola Picotti will discuss the p
 ower and limitations of the new approach and present her vision on the fut
 ure of proteomics.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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