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BEGIN:VEVENT
SUMMARY:Microtubule shaft dynamics
DTSTART:20181214T130000
DTEND:20181214T140000
DTSTAMP:20260407T103349Z
UID:81e13949b237aa0848c1ff0b606693f958462f6bdc49a599f1fd238f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Charlotte Aumeier - currently works at the Department of Bioch
 emistry\, University of Geneva. Charlotte does research in Marine Biology\
 , Cell Biology and Molecular Biology\nMicrotubules are dynamic polymers co
 mposed of tubulin subunits which are organized in a highly controlled dens
 e network. Individual microtubules undergo dynamic instability: they stoch
 astically switch between growing and shrinking at the microtubule tip. Thi
 s seems to imply that the control of the network dynamics occurs at the fi
 lament tips\, while the tube itself ("the shaft") appears like a passive e
 lement. Is the shaft really passive? Recent works\, shows that tubulin sub
 units exchange along the shaft results in patches "freshly"-incorporated G
 TP-tubulin. Here I will show how these GTP- patches cause an effective pro
 longation of the microtubule lifetime\, because they promote regrowth. A l
 ocal regulation of microtubule lifetime e.g. by specific photo-manipulatio
 n of the microtubule shaft can indeed challenge the cell polarity. I will 
 further show that kinesin motor proteins remove tubulin subunits from the 
 shaft as they walk\, thereby stabilizing those particular microtubules whi
 ch are most used for trafficking.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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