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SUMMARY:Engineering Bioluminescent Sensor Proteins and Beyond: from Point-
 of-Care Diagnostics to DNA-Based Molecular Computing
DTSTART:20181210T140000
DTEND:20181210T150000
DTSTAMP:20260408T071215Z
UID:35290d0995d1d01e64beabb08052509bd4286880a1f2320641c61cca
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Maarten Merkx\, Eindhoven University of Technology (NL)\
 nBIOENGINEERING SEMINAR\n\nAbstract:\nIn my presentation I’ll show how m
 odular protein sensor design strategies originally developed for FRET sens
 or proteins are easily adapted for the development of robust BRET and dual
  BRET/FRET sensors. In particular I’ll focus on the development of vario
 us BRET-based homogenous assays that allow detection of antibodies (LUMABS
 \; LUMinescent AntiBody Sensors)\, small molecules\, proteins and DNA/RNA 
 directly in complex matrices such as blood plasma. In addition to developi
 ng BRET-based homogenous immunoassays for point-of-care diagnostics\, my g
 roup is also exploring more complex biomolecular systems that can integrat
 e sensing of multiple analytes\, signal processing and actuation all on a 
 molecular level. In my lecture I’ll present generic strategies that comb
 ine protein-based sensing and actuation with DNA-based computing\, includi
 ng efforts to confine and accelerate these molecular computational network
 s  by templating on supramolecular polymers.\n\nBio:\nMaarten Merkx studi
 ed physical organic chemistry and biochemistry at the Radboud University N
 ijmegen (1995\, cum laude). He did his PhD with Prof. Averill (1999\, Univ
 ersity of Amsterdam) working on purple acid phosphatases\, and was an HSFP
  post-doctoral fellow with Prof. Lippard (MIT\, 1999-2001). Currently he i
 s a professor in protein engineering at the Eindhoven University of Techno
 logy and a core member of the Institute for Complex Molecular Systems (ICM
 S). His group combines approaches from protein engineering\, chemical biol
 ogy\, and synthetic biology to develop biomolecular sensors and actuators 
 for applications in intracellular imaging\, point-of-care diagnostics\, an
 d antibody-based therapies. An important research theme is the engineering
  of biomolecular switches\, which include fluorescent and bioluminescent s
 ensor proteins for intracellular imaging\, photo-switchable proteins\, and
  protein- and DNA-based sensors for antibody detection and actuation. Prof
 . Merkx has published 115+ research papers and is associate editor for ACS
  Sensors.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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