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SUMMARY:Toward Real-World Applications of DNA Origami Nanostructures
DTSTART:20190218T121500
DTSTAMP:20260919T052643Z
UID:b03e813ddfba55dcdad798ac02918c79863ffc125045def937ec5597
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Adrian Keller\, Paderborn University (D)\nintroducing: W
 EEKLY BIOENGINEERING COLLOQUIA SERIES\n(sandwiches served)\n\nAbstract: \n
 DNA origami is the folding of a long\, single-stranded DNA scaffold into a
  desired nanoscale 2D or 3D shape by hybridization with a set of synthetic
  oligonucleotides. The resulting DNA origami nanostructures exhibit some p
 roperties that make them highly attractive for various medical and technol
 ogical applications. First\, DNA origami nanostructures can be assembled i
 n well-defined yet almost arbitrary sizes and shapes and thus be tailored 
 to meet the specific requirements of a given application. Second\, whereas
  many organic and inorganic nanoparticle systems have raised concerns rega
 rding possible nanotoxicity\, DNA nanostructures are intrinsically biocomp
 atible and biodegradable\, and do not show any cytotoxicity. Third\, the s
 urfaces of DNA origami nanostructures can be modified with unprecedented m
 olecular accuracy to display various functional entities.\nConsequently\, 
 DNA origami nanostructures are nowadays synthesized on a routine basis in 
 hundreds of labs around the world. However\, despite this growing populari
 ty in academia and the impressive recent advancements of the DNA origami t
 echnique such as automated design strategies and biotechnological mass pro
 duction\, real-world applications of DNA origami remain scarce. This is be
 cause of a number of so far unmet challenges that currently limit the inte
 gration of DNA origami nanostructures with established technologies and co
 ncepts. This talk will provide an overview of our recent and ongoing activ
 ities aimed at employing DNA origami nanostructures as molecular tools in 
 the fields of drug discovery\, drug delivery\, and molecular lithography. 
 In particular\, it will address current application-specific challenges re
 garding the analysis\, stability\, and immobilization of DNA origami const
 ructs.\n\n \n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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